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BT-CoQ10 BIO-TRANSFORMED ® |
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Bio-Transformed® Vitamins & Minerals
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BIO-AVAILABILITY IN HUMAN SERUM GLUTATHIONE and GLUTATHIONE PEROXIDASE ACTIVITY LEVELS IN HUMAN SERUM: DISCUSSION – HOW YEAST FERMENTATION MAKES SUCH A POSITIVE DIFFERENCE BIO-AVAILABILITY IN HUMAN SERUM KGK Synergize of Ontario, Canada compared bio-availability of our BT-CoQ10 with standard commercial grade CoQ10. A DIFFERENT COMPARISON: They compared Two Products with The Same Delivery System - Commercial grade CoQ10 and BT-CoQ10 in identical capsules containing identical oil. Previous studies compared One Product with Two Delivery Systems - Commercial grade CoQ10 in standard capsules containing standard oil, and homogenized into an oil base with agents such as vitamin E and surfactants. RESULTS: Bio-availability of Bio-Foods ® BT-CoQ10 was 2.6 times greater than commercial grade. The maximum blood level peak was 2.26 times higher for Bio-Foods ® BT-CoQ10 than for commercial grade. The time it took to reach that maximum peak was 30 minutes sooner for Bio-Foods ® BT-CoQ10 than for commercial grade. The superior performance of BT-CoQ10 is especially noteworthy considering that the dose given by the researchers was a megadose about 10 times higher than a typical daily dose. A human body can only absorb so much of a particular nutrient at one time (its maximum threshold limit), so when it is flooded with a megadose of a nutrient, even a poorly absorbed form, the sheer quantity forces the amount absorbed toward the maximum limit for that nutrient, thereby reducing the usual difference in relative absorbability between the forms as when consuming a normal dose. Considering that healthy young subjects received 10 days worth of CoQ10 each day, our result of 2.6 times more absorption (as well as the other results discussed below) is a very respectful number indeed. In addition, higher peak levels and shorter times to reach those peaks indicate a superior ease of absorption for BT-CoQ10. GLUTATHIONE and GLUTATHIONE PEROXIDASE ACTIVITY LEVELS IN HUMAN SERUM: KGK Synergize also compared Glutathione levels and Glutathione Peroxidase activity with consumption of BT-CoQ10 and commercial grade CoQ10. AN ADDED DIMENTION OF RESEARCH: CoQ10 has attracted attention as an antioxidant. However, we are unaware of any previous bio-availability study that also measured the product’s reduction of overall oxidative stress the way we believe this study did. If not a first, it is certainly an uncommon opportunity to see data on this benefit of CoQ10. RESULTS: Glutathione levels were reduced by about the same amount in both groups (1% further in the BT-CoQ10 group). Glutathione Peroxidase Activity increased 13% less in the BT-CoQ10 group. PERSPECTIVE: Contrary to a common assumption that an increasing number is always better than a decreasing number, or that a greater quantity of a good thing is better than a smaller quantity, we must avoid that assumption when evaluating results for serum Glutathione and Glutathione Peroxidase Activity. For example, if one were to monitor immune system strength of a subject with a severe case of flu, finding it to be increasing would be ‘good’. But when the flu is conquered by the subject’s immune system, finding it to be decreasing is also ‘good’. In periods of reduced oxidative stress the body requires lower levels of serum Glutathione and Glutathione Peroxidase Activity (which helps Glutathione to function). We believe our results strongly suggest Bio-Foods ® BT-CoQ10 did a better job of lowering overall oxidative stress in the subjects than did the commercial grade. DISCUSSION – HOW YEAST FERMENTATION MAKES SUCH A POSITIVE DIFFERENCE Now that we have these excellent study results, it is natural to consider how and what yeast does to enhance bio-availability of CoQ10. Here is our view. YEAST IS NATURE’S PREMIER “STRUCTURAL ENGINEER”: Plasma membranes of yeast cells, like those of human cells, have substantial amounts of Coenzyme Q. The inner mitochondrial membranes, lipoproteins, and intracellular membranes of yeast cells, like those of human cells, contain Coenzyme Q. Yeast cells therefore have the “know-how” of Nature to synthesize and build utilizable complexes and formations of Coenzyme Q. Pure commercial grade CoQ10 is believed to be poorly absorbed partly because it tends to clump together. In Nature, CoQ10 tends to be found as part of a lipid matrix inside bilayer membranes, with its molecular heads and water-hating tails arranged in a typical manner (Quinn P. J. Topography of Coenzyme Q in membranes. Coenzyme Q: Molecular mechanisms in health and disease. Kagan and Quinn eds. CRC Press LLC. 2001).
Figure 1. Schematic molecular model of Co Q-10 in lipid bilayer matrix. It would be difficult and hugely expensive, if not impossible, to mimic Nature’s bilayer form by subjecting commercial grade CoQ10 to sophisticated mixing and homogenizing techniques in a laboratory. Yeast on the other hand builds nutrient complexes and molecular arrangements every day for a living. In the January 1999 issue of Prepared Foods, Daniel Best, a technology development consultant was quoted “…yeast…can be manipulated to collect and concentrate a variety of nutrients. Interest will grow in using these micro-organisms as delivery vehicles for value added nutrients…”. Saccharomyces cerevisiae yeast has a very unique transportation enzyme superfamily, the ABC protein complex, which can transport almost any biological substance, regardless of its physical properties (Winkle, 1995). This flexibility gives this yeast an optimum interactive ability with materials in the fermentation media. YEAST IS A NUTRIENT POWERHOUSE: Yeast cells also contain other antioxidants such as glutathione and superoxide dismutase (S.O.D.), which compliment the total antioxidant defense system. According to one report, research in Europe suggests “CoQ10 absorbability in rats can be improved by supplying the amino acids, fatty substances, and enzymes in brewer’s yeast (Saccharomyces cerevisiae) that favor CoQ10 absorption”. Not merely a CoQ10 product! BT-CoQ10 is a Premium Synergy Nutrient complete with super antioxidant nutrients plus phytonutrients and a full spectrum of vital cofactor mineral nutrients and other life-giving cell constituents. For example, 400 MG of CoQ10 Yeast powder in a capsule provides 30 MG of CoQ10 plus the following Approximate Nutrient Profile. 120 MG Amino Acids 30 MG Lipids, including Phosphatidyl Choline, Phosphatidyl Serine, Omega 3 Fatty Acids, Phytosterols. 120 MG Carbohydrates, including Glycogen, Oligosaccharides. 0.04 MG Glutathione 2 MG Beta Glucans 8 MG RNA/DNA 65 MG Nutrients and Phytonutrients, including Saponins, Minerals, Vitamins, S.O.D., Polyphenols, Plant Flavones, Isoflavones. These nutrients are an integral part of the food matrix as well; not just a blend but part of a whole food. They all work synergistically together for added benefit. A fair cost comparison will take this into account. |
